Plastic Eye Drop Bottle Forming Filling And Sealing Machine

Plastic Eye Drop Bottle Forming Filling And Sealing Machine

Characteristics: The biggest advantage of BFS is reduce outer pollution —human contamination, environment pollution and material pollution, which can be sure product safety . Package The process is versatile and a wide variety of containers of different sizes can be made on the machine. The size...

Characteristics:

The biggest advantage of BFS is reduce outer pollution —human contamination, environment pollution and material pollution, which can be sure product safety .


Package

The process is versatile and a wide variety of containers of different sizes can be made on the machine. The size may range from 0.2ml to 13 litres. For convenience, the sizes of containers are classified in the following three categories:

-Small Volume Packaging: For containers from 0.2ml up to volume of 50ml.

-Large Volume Packaging: For containers from 50ml up to 500ml.

-Very Large Volume Packaging : For containers above 2500ml.


Structure


There are two structure type of BFS machine ,black/white zoning and without black/white zoning.


1. BFS machine conforms to Black/White zoning configuration and this module configuration separates filling(white zone)

from auxiliary device zone(black zone). All particles source are placed into auxiliary device zone(black zone). Auxiliary device

zone to filling zone(white zone) keeps negative pressure, so the clean room space decreases greatly.


2. BFS machine conforms to without Black/White zoning configuration and this configuration is to be the entire device placed

in the C class zone. This structure occupied clean area is relatively large , but the overall size of the device is relatively small.

Development Tendency

From the development trend of the pharmaceutical industry, the traditional open type aseptic production environment and over a number of personnel to participate can not meet the growing demand for the production of sterile preparations. The BFS technology which can achieve automation and isolate will be the future development direction of sterile preparations.


The process of BFS is not only with the requirements of GMP, but also is the development trend of sterile drug products in China. The BFS technology which will replace glass ampoules and glass bottle infusion will become the mainstream of sterile drug products .


Blow-fill-seal Process


1. The mould is transferred to blowing/filling station quickly. The blowing/filling/sealing

mandrels are protected against contamination by sterile air in the aseptic air chamber. The blowing /filling nozzle is lowered into the parison until it forms a seal with the neck

of the mold. The plastic material is now formed into a container as determined by the design of the mould by vacuum and /or sterile air pressure.


2. The container is immediately filled with a metered volume of the solution, displacing the

sterile air. Both the air and the solution are filtered through bacteria retaining filters

immediately before entry into the forming, or formed container. Pipe contacting with

solution can realize CIP and SIP before filling, so that it ensures drug solution safety.


3. After filling, the tube parison between top of plastic mould and the holding jaws

remains semi-melting condition, and then sealed mould closes and forms the top of

container and keeps the containers sealed.


4. After sealed, the plastic mould is opened. The container is totally formed,

filled, sealed and is ready to out feed and then starts next cycle.




Capacity


It is mainly used for small volume injection, eye drops, and oral liquid and ear drops with the range of 0.2ml~20ml.Each device could product 4800~16000 per hour,



model type

Specifications

Ext Number

Model num

total cavity

capacity
(pcs/h)

SED-BFS-01

500mL

6

1

6

1150

1000mL

6

1

6

1080

SED-BFS-02

100mL

8

1

8

1950

250mL

8

1

8

1800

500mL

8

1

8

1550

SED-BFS-03

500mL

6

2

12

2350

1000mL

6

2

12

2160

SED-BFS-04

100mL

8

2

16

4000

250mL

8

2

16

3600

500mL

8

2

16


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